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Penn - meet once per week to discuss topics in synaptic physiology an d to become proficient at sharp electrode techniques for intracellular recording, using isolated ganglia from the snai l Heliosoma. The first part of each class will consist of discussion of weekly reading from the primary literature, wit h the remainder of the class devoted to hands-on experiments. After learning to record from and characterize singl e neurons, students will study synaptic transmission by stimulating incoming nerve trunks or by recording from pairs o f interconnected neurons. As a midterm assignment, students will prepare and present a short research proposal usin g this model system, to be evaluated by the class. For the last half of the course, the class will work together on one o r two of these proposals, meeting at the end of each class to pool our data, analyze the results and discuss thei r significance . 499. Senior Honors Thesis.

C) Standing Faculty. Prerequisite(s): BIBB 399, permission of BIBB Director and a GPA of
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Penn - : BIBB 400 . Continuation of BIBB 399 research. Students will be required to present their oral defense and a poster at the annua l BBB Symposium . <A href="http://www.upenn.edu/" target="_blank" onMouseOver="imgSwap

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Penn - Introduction to Brain and Behavior.

C)
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Penn - Visual Neuroscience.

B)
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Penn - Physiology of Motivated Behaviors.

C)
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Penn - Animal Behavior.

C)
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Penn - Cognitive Neuroscience.

C)
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Penn - Molecular and Cellular Neurobiology

formerly Cellular Neurobiology). (A)
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Penn - Neuroendocrinology.

C)
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Penn - Miselis. Prerequisite

s): BIBB 109 or
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Penn - Newberg. Prerequisite

s): BIBB 109
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Penn - Genetics, Evolution, and Behavior.

C)
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Penn - Behavioral Genetics.

K)
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Penn - Prerequisite

s): BIBB 109 or 269 or 380, or permission of instructor. This course examines the history, rationale and putative mechanism of action of drugs used in the treatment of psychiatric disorders. Emphasis is placed on neurobiological processes underlying psychopathology and pharmacological intervention. Drugs currently in use as well as new drugs in development will be covered. Strategies, techniques, issues and challenges of clinical psychopharmacological research will be addressed and new approaches to drug discovery, including the use of pharmacogenomics and proteomics to understand variability in drug response and identify new molecular drug targets, will be covered in depth. Specific drug classes to be considered include antidepressants, anxiolytics, typical and atypical antipsychotics, narcotic analgesics, sedative hypnotics, and antiepileptic medications. A contrasting theme throughout the course will be the use of drugs as probes to identify neural substrates of behavior.
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Penn - Kaplan. Prerequisite

s): BIBB 109 and BIBB 251.
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Penn - Living World Sector. All classes. Medina and Muzzio. Introduction to the structure and function of the vertebrate nervous system. We begin with the cellular basis of neuronal activities, then discuss the physiological bases of motor control, sensory systems, motivated behaviors, and higher mental processes. This course is intended for students interested in the neurobiology of behavior, ranging from animal behaviors to clinical disorders. Familiarity with elementary physics and chemistry may be helpful. L/R

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Penn - Staff. Prerequisite(s): BIBB 109, PSYC 001, COGS 001 or VLST 101 . An introduction to the scientific study of vision, with an emphasis on the biological substrate and its relation t o behavior. Topics will typically include physiological optics, transduction of light, visual thresholds, anatomy an d physiology of the visual pathways, retinal processing, properties of visual cortex, and color vision .

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Penn - May be counted as a General Requirement Course in Living World. Class of 2009 & prior only. Grill . The regulatory physiology of motivation will be discussed in detail, including the coordination of behavioral and neura l mechanisms in motivation .

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Penn - May be counted as a General Requirement Course in Livin g World. Class of 2009 & prior only. Seyfarth/Cheney. Prerequisite(s): PSYC 001 or BIOL 102 or BIOL 122 . The evolution of social behavior in animals, with special emphasis on group formation, cooperation among kin, matin g systems, territoriality and communication .

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Penn - Dinges. Prerequisite(s): PSYC 001 and one year of biology . Topics to be covered include basic principles of chronobiology; neuroscience mechanisms of circadian rhythms an d sleep; phylogeny and ontongeny of sleep; human sleep and sleep disorders; circadian dysfunction; circadian and slee p homeostatic influences in human health and safety . L/R

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Penn - Living World Sector. All classes. Thompson-Schills. Prerequisite(s): PSYC 001 or BIBB/PSYC 109 . The study of the neuronal systems that underlie human perception, memory and language; and of the pathologica l syndromes that result from damage to these systems . L/L

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Penn - Schmidt , M./Abel/Peachey. Prerequisite(s): BIOL 101 and 102, or BIOL 121; PHYS 102 or 151 strongly recommended. Lab fe e $150. (3hrs. lec., 3hrs. lab, 1.5 c.u.) . Cellular physiology of neurons and excitable cells; molecular neurobiology and development. Topics include: actio n potential generation; synaptic transmission; molecular and physiological studies of ion channels; second messengers ; simple neural circuits; synaptic plasticity; learning and memory; and neural development .

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Penn - Flanagan-Cato. Prerequisite(s): BIBB 109, one year of Biology, o r Permission of Instructor . This course is designed to examine the various roles played by the nervous and endocrine systems in controlling bot h physiological processes and behavior. First, the course will build a foundation in the concepts of neural and endocrin e system function. Then, we will discuss how these mechanisms form the biological underpinnings of various behavior s and their relevant physiological correlates. We will focus on sexual and parental behaviors, stress, metabolism , neuroendocrine-immune interactions, and mental health .

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Penn - Heerding. Prerequisite(s): BIBB 109 or Permission of Instructor . This lecture course is designed to introduce the student to the functioning of the autonomic nervous system (ANS) , which is critically involved in the maintenance of body homeostasis through regulation of behavior and physiology . The course will begin with a review of the basic anatomy and physiology of the ANS including the sympathetic , parasympathetic and enteric divisions. The mechanisms by which the ANS regulates peripheral tissues will b e discussed, including reflex and regulatory functions, as will the effect of drugs which modulate ANS activity. The rol e of the ANS in regulating behavior will be addressed in the context of thirst, salt appetite and food intake. Finally, th e course will cover the result of over-activation of the sympathetic nervous system as manifested in chronic stress . (PSYC125) Drugs, Brain and Mind. (B) Peoples. Prerequisite(s): BIBB 209, Intro Biology and Intro Psychology. The course will begin with a review of basic concepts in pharmacology including: routes of drug administration, drug metabolism, the dose response curve, tolerance and sensitization. Following a brief overview of cellular foundations of neuropharmacology (cell biology, synaptic and receptor function), the course will focus on various classes of drugs used to treat neuropsychiatric disorders including, among others, depression, schizophrenia and anxiety. We will additionally consider mechanisms mediating the mind-altering, addictive and neurotoxic effects of abused drugs.

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Penn - Miselis. Prerequisite(s): BIBB 109 or permission of instructor. Lab Fee: $100 . A laboratory course designed to familiarize the student with the fundamental gross and histological organization of th e brain. The mammalian brain will be dissected and its microscopic anatomy examined using standard slide sets . Comparative brain material will be introduced, where appropriate, to demonstrate basic structural-functiona l correlations .

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