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department Biology (X) |
7.012 Introductory Biology ( ) Units: 5-0-7 Credit cannot also be received for 7.013 , 7.014 URL: http://mit.edu/7.01x/ Lecture: MWF10 ( 26-100 ) Recitation: MW12 ( 26-204 ) or MW1 ( 26-204 ) or MW2 ( 26-204 , 26-210 ) or MW3 ( 26-210 ) or MW4 ( 26-210 ) or TR9 ( 26-210 ) or TR10 ( 26-210 , 26-204 , 12-122 ) or TR11 ( 26-210 , 26-204 , 12-122 ) or TR12 ( 26-210 , 26-204 ) or TR1 ( 26-210 , 26-204 ) or TR2 ( 26-210 , 26-204 ) or TR3 ( 26-210 ) or TR4 ( 26-210 ) +final 7.013 Introductory Biology ( ) Units: 5-0-7 Credit cannot also be received for 7.012 , 7.014 7.014 Introductory Biology ( ) Units: 5-0-7 Credit cannot also be received for 7.012 , 7.013 All three subjects cover the same core material, which includes the fundamental principles of biochemistry, genetics, molecular biology, and cell biology. In addition, each version of the subject has its own distinctive material, described below. The core material focuses on function at a molecular level: the structure and regulation of genes, and the structure and synthesis of proteins; how these molecules are integrated into cells; how cells are integrated into multicellular systems and organisms; and computational and genomic approaches to biology. 7.012 and 7.013 are similar, as both emphasize current issues in human biology. 7.012 focuses slightly more on genetic approaches, 7.013 on development and neurobiology. Fall Term: 7.012. Exploration into areas of current research in cell biology, immunology, neurobiology, human genetics, developmental biology, and evolution. Spring Term: 7.013. Application of the fundamental principles toward an understanding of human biology. Topics include genetics, cell biology, molecular biology, disease (infectious agents, inherited diseases and cancer), developmental biology, neurobiology and evolution. Spring Term: 7.014. Application of the fundamental principles toward an understanding of microorganisms as geochemical agents responsible for the evolution and renewal of the biosphere and of their role in human health and disease. Topics include biogeochemical cycles; population growth; ecosystem ecology; microbial diversity. Fall: 7.012: E. Lander, R. Weinberg Spring: 7.013: T. Jacks, H. Sive; 7.014 G.C. Walker, S.W. Chisholm
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7.02 Introduction to Experimental Biology and Communication ( , ) (Subject meets with 10.702 ) Prereq: Biology (GIR) Units: 4-8-6 URL: http://web.mit.edu/7.02/ Lecture: TR11 (1ST MTG 9/10 MANDATORY) ( 54-100 ) Lab: TR1-5 ( 68-074 ) or WF1-5 ( 68-074 ) Recitation: M9-11 ( 1-115 ) or T9-11 ( 1-115 ) or W9-11 ( 1-115 ) or M1-3 ( 1-115 , 14-0637 ) or T1-3 ( 14-0637 ) or W1-3 ( 14-0637 ) +final An introduction to the experimental concepts and methods of molecular biology, biochemistry, and genetic analysis. Emphasis on experimental design, critical data analysis, and the development of written communications skills. Twelve units may be applied to the General Institute Laboratory Requirement. Enrollment limited. Fall: L. Boyer, W. Gilbert Spring: D. Kim, T. Schwartz
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7.03 Genetics ( , ) Prereq: Biology (GIR) Units: 4-0-8 URL: http://web.mit.edu/7.03 Lecture: MWF11 ( 54-100 ) Recitation: M1 ( 26-310 ) or M2 ( 26-310 ) or M3 ( 26-310 ) or M4 ( 26-310 ) or T10 ( 3-343 ) or T11 ( 3-343 ) or T12 ( 26-310 ) or T1 ( 26-310 ) or T2 ( 26-310 ) +final The principles of genetics with application to the study of biological function at the level of molecules, cells, and multicellular organisms, including humans. Structure and function of genes, chromosomes, and genomes. Biological variation resulting from recombination, mutation, and selection. Population genetics. Use of genetic methods to analyze protein function, gene regulation, and inherited disease. Fall: G. Fink, P. Reddien Spring: C. Kaiser, A. Regev
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7.05 General Biochemistry ( ) Prereq: 5.12 , Biology (GIR) , or permission of instructor Units: 5-0-7 Credit cannot also be received for 5.07 URL: http://mit.edu/7.05 Contributions of biochemistry toward an understanding of the structure and functioning of organisms, tissues, and cells. Chemistry and functions of constituents of cells and tissues and the chemical and physical-chemical basis for the structures of nucleic acids, proteins, and carbohydrates. General metabolism of carbohydrates, fats, and nitrogen-containing materials such as amino acids, proteins, and related compounds. M. Yaffe, G. M. Brown, P. Chang
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7.06 Cell Biology ( , ) Prereq: 7.03 , 7.05 Units: 4-0-8 URL: http://web.mit.edu/7.06 Lecture: MW9.30-11 ( 4-370 ) Recitation: F11 ( 26-204 ) or F12 ( 26-204 ) or F1 ( 26-204 ) or F2 ( 26-204 ) +final Biology of cells of higher organisms: structure, function, and biosynthesis of cellular membranes and organelles; cell growth and oncogenic transformation; transport, receptors, and cell signaling; the cytoskeleton, the extracellular matrix, and cell movements; cell division and cell cycle. Fall: A. Amon, H. Lodish Spring: I. Cheeseman, T. Orr-Weaver
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7.08J Biological Chemistry II ( ) (Same subject as 5.08J ) (Subject meets with 7.80 ) Prereq: 5.12 ; 5.07 or 7.05 Units: 4-0-8 More advanced treatment of biochemical mechanisms that underlie biological processes. Topics include macromolecular machines such as the ribosome, the proteosome, fatty acid synthases as a paradigm for polyketide synthases and non-ribosomal polypeptide synthases, and polymerases. Emphasis is on experimental methods used to unravel these processes and how these processes fit into the cellular context and coordinate regulation. A. Y. Ting, E. Nolan
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7.10J Physical Chemistry of Biomolecular Systems ( ) (Same subject as 20.111J ) Prereq: Calculus II (GIR) , Chemistry (GIR) , Physics I (GIR) ; Coreq: Physics II (GIR) Units: 5-0-7 Credit cannot also be received for 20.110 Provides a quantitative approach to understanding the physical and chemical laws that govern the behavior of biological macromolecules. Basic thermodynamics, state of a system, state variables. Work, heat, first, second, and third laws of thermodynamics. Entropy and its statistical basis, free energy representations, Legendre transforms, Maxwell relations, Gibbs function, Boltzmann distribution and partition functions. Equilibrium properties of macroscopic and microscopic systems; macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding, cooperativity, solvation, and titration of macromolecules. Applications of introductory quantum mechanics to spectroscopy. Staff
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7.11 Biology Teaching ( , ) Prereq: None Units arranged TBA. For qualified undergraduate students interested in gaining some experience in teaching. Laboratory, tutorial, or classroom teaching under the supervision of a faculty member. Students selected by interview. Consult Biology Education Office
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7.13 Experimental Microbial Genetics ( ) Prereq: 7.02 , 7.03 , 7.05 Units: 4-16-10 URL: http://web.mit.edu/7.13 Lecture: MTWRF1 ( 68-121 ) Lab: MTWRF2-5 ( 68-089 ) Molecular genetics used to examine the biology of the bacterium Pseudomonas aeruginosa PA14, an opportunistic pathogen isolated from the lungs of cystic fibrosis patients. Students engage in independent research projects to probe various aspects of Pseudomonas aerguinosa physiology including survival in stationary phase, antibiotic resistance, phase variation, toxin production, and secondary metabolite production. Projects aim to discover the molecular basis for these processes using both classical and cutting-edge techniques. These include plasmid manipulation, genetic complementation, mutagenesis, PCR, DNA sequencing, enzyme assays, and gene expression studies. Instruction and practice in written and oral communication are also emphasized. Enrollment limited. M. Laub, D. Newman
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7.16 Experimental Molecular Biology: Biotechnology II ( ) Prereq: 7.02 , 7.03 , 7.05 Units: 4-16-10 URL: http://web.mit.edu/7.16 Applies emerging high-throughput genetic approaches to study the response of mammalian cells to cytotoxic or infectious stimuli. RNA interference (RNAi) screening, microarray expression analysis, and massively parallel sequencing will be used to examine the genetics of cellular pro-survival and pro-death pathways. Teams of two or three students design and carry out experiments to address questions regarding the mechanisms that govern the regulation and execution of cellular responses. Some projects involve the use of DNA damaging agents or other cytotoxic drugs to help understand the pathways that control a cell's response to chemotherapy. Other projects examine the genes that underlie the cellular response to pathogens. Instruction and practice in written and oral communication provided. M. Hemann, J. Saeij
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7.17 Experimental Molecular Biology: Biotechnology III ( ) Prereq: 7.02 , 7.03 , 7.05 Units: 4-16-10 Cell and molecular biology lab that uses recombinant DNA methods and optical microscopy to study cellular mechanisms in eukaryotic cells. Projects focus on mechanisms of intracellular protein translocation and cytoskeletal rearrangement. Students explore the recombinant fluorescent proteins using imaging techniques and describe the effects of the expressed protein on cell motility, the cell cycle, or the organization and function of cytoplasmic organelles and the cyoskeleton. Projects involve many techniques, such as DNA sequence analysis, RNAi, RT-PCR, and Western blotting. Instruction and practice in written and oral communication provided. F. Gertler, M. L. Pardue
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7.18 Topics in Experimental Biology ( , ) (Subject meets with 7.19 ) Prereq: 7.02 , 7.03 , 7.05 Units: 4-16-10 Credit cannot also be received for 7.19 Compulsory: 1st Mtg Sept 10 At 2 Pm ( 68-180 ) Lecture: TR2-4 ( 68-374 , 68-274 ) Independent experimental study under the direction of a member of the Biology Department faculty. Allows students with a strong interest in independent research to fulfill the project laboratory requirement for the Biology Department Program in the context of a research laboratory at MIT. The research should be a continuation of a previous project. Written and oral presentation of the research results is required. Journal club discussions are used to help students evaluate and write scientific papers. Instruction and practice in written and oral communication is provided. Permission of the faculty research supervisor and the Biology Education Office must be obtained in advance. Fall: M. L. Pardue, A. J. Sinskey Spring: S. Lindquist, N. Hopkins
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7.19 Communication in Experimental Biology ( , ) (Subject meets with 7.18 ) Prereq: 7.02 , 7.03 , 7.05 Units: 4-4-4 Credit cannot also be received for 7.18 Compulsory: 1st Mtg Sept 10 At 2 Pm ( 68-180 ) Lecture: TR2-4 ( 68-374 , 68-274 ) Students carry out independent literature research. Meets with the seminar and writing tutorial portions of 7.18. Journal club discussions are used to help students evaluate and write scientific papers. Instruction and practice in written and oral communication is provided. Permission of the instructor and the Biology Education Office must be obtained in advance. Fall: M. L. Pardue, A. J. Sinskey Spring: S. Lindquist, N. Hopkins
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7.20J Human Physiology ( ) (Same subject as HST.540J ) Prereq: 7.05 Units: 5-0-7 URL: http://mit.edu/7.20 Lecture: TR9-11 ( E25-111 ) Recitation: M3 ( 56-167 ) or W11 ( 56-180 ) or R12 ( 66-168 ) or R EVE (7 PM) ( 56-167 ) +final Comprehensive subject in human physiology, emphasizing the molecular basis and applied aspects of organ function and regulation in health and disease. Includes a review of cell structure and function, as well as the mechanisms by which the endocrine and nervous systems integrate cellular metabolism. Special emphasis on examining the cardiovascular, pulmonary, gastrointestinal, and renal systems. M. Krieger, D. Sabatini
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7.21 Microbial Physiology ( ) (Subject meets with 7.62 ) Prereq: 7.03 , 7.05 Units: 4-0-8 Lecture: MW11-1 ( 66-144 ) Recitation: W4 ( 66-154 ) Biochemical properties of bacteria and other microorganisms that enable them to grow under a variety of conditions. Interaction between bacteria and bacteriophages. Genetic and metabolic regulation of enzyme action and enzyme formation. Structure and function of components of the bacterial cell envelope. Protein secretion with a special emphasis on its various roles in pathogenesis. Additional topics include bioenergetics, symbiosis, quorum sensing, global responses to DNA damage, and biofilms. Students taking the graduate version are expected to explore the subject in greater depth. G. C. Walker, B. Magasanik, D. Newman
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7.22 Development and Evolution ( ) Prereq: 7.03 , 7.06 Units: 5-0-7 URL: http://mit.edu/7.22 Lecture: TR11.30-1 ( 26-314 ) Recitation: R EVE (7 PM) ( 26-314 ) or F11 ( 26-302 ) +final Covers animal development and evolution. Topics include origins of multicellularity, the germline, formation of early body plans, cell type determination, organogenesis, morphogenesis, stem cells, cloning, evolution of developmental diversity and processes, developmental genetics, and issues in human development. Experimental approaches to problems of development and evolution, including the study of vertebrate (mouse, chick, frog, fish) and invertebrate (fly, worm) models, will be covered. M. Constantine-Paton, P. Reddien
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7.23 Immunology ( ) (Subject meets with 7.63 ) Prereq: 7.03 , 7.05 , 7.06 , or permission of instructor Units: 5-0-7 A comprehensive survey of molecular, genetic, and cellular aspects of the immune system. Topics include innate and adaptive immunity; cells and organs of the immune system; immunoglobulin, T cell receptor, and major histocompatibility complex (MHC) genes and structure; development and functions of B and T lymphocytes; immune responses to infections and tumors; hypersensitivity, autoimmunity, and immunodeficiencies. Particular attention is paid to the development and function of the immune system as a whole as studied by modern methods and techniques. H. Ploegh, L. Steiner
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7.24 The Protein Folding Problem ( ) Prereq: 7.05 or 5.07 Units: 4-2-6 Mechanisms by which the amino acid sequence of polypeptide chains determines their three-dimensional conformation. Topics include: sequence determinants of secondary structure; folding of newly synthesized polypeptide chains within cells; unfolding and refolding of proteins in vitro ; folding intermediates aggregation and competing off-pathway reactions; role of chaperonins, isomerases, and other helper proteins; protein recovery problems in the biotechnology industry; diseases associated with protein folding defects. J. A. King
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7.25 Biological Regulatory Mechanisms ( ) Prereq: 7.02 , 7.03 , 7.05 Units: 4-0-8 Cells utilize a variety of mechanisms to regulate gene expression, growth, development, and behavior in response to both external and internal conditions. Examines basic principles of biological regulation, focusing on several well-studied examples, usually drawn from microbial species. Reading includes primary literature and review articles with emphasis on how we know what we know, and how to think experimentally. B. Magasanik, U. RajBhandary
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7.26 Molecular Basis of Infectious Disease (New) ( ) (Subject meets with 7.66 ) Prereq: 7.03 , 7.05 , 7.06 Units: 4-0-8 Focuses on the principles of host-pathogen interactions with an emphasis on infectious diseases of humans. Presents key concepts of pathogenesis through the study of various human pathogens. Lectures accompanied by readings that illustrate modern experimental molecular methodologies. Students taking graduate version complete additional assignments. D. Kim, J. Saeij
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7.27 Principles of Human Disease ( ) Prereq: 7.03 , 7.05 , 7.06 Units: 4-0-8 Covers current understanding of and modern approaches to human disease, emphasizing the molecular and cellular basis of both genetic disease and cancer. Topics include the genetics of simple and complex traits; karyotypic analysis and positional cloning; genetic diagnosis; the roles of oncogenes and tumor suppressors in tumor initiation, progression, and treatment; the interaction between genetics and environment; animal models of human disease; cancer; and conventional and gene therapy treatment strategies. D. Housman, L. Guarente
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7.28 Molecular Biology ( ) (Subject meets with 7.58 ) Prereq: 7.03 ; Coreq: 7.05 Units: 5-0-7 Detailed analysis of the biochemical mechanisms that control the maintenance, expression, and evolution of prokaryotic and eukaryotic genomes. Topics covered in lecture and readings of relevant literature include: gene regulation, DNA replication, genetic recombination, and mRNA translation. Logic of experimental design and data analysis emphasized. Presentations include both lectures and group discussions of representative papers from the literature. Students taking the graduate version are expected to explore the subject in greater depth. T. Baker, S. Bell
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7.29J Cellular Neurobiology ( ) (Same subject as 9.09J ) Prereq: 7.05 Units: 4-0-8 URL: http://web.mit.edu/7.29j/ Introduction to the structure and function of the nervous system. Emphasizes the cellular properties of neurons and other excitable cells. Includes the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, integration of information in simple systems, and detection and information coding during sensory transduction. W. G. Quinn, J. T. Littleton
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7.30J Ecology I: The Earth System ( ) (Same subject as 1.018J ) Prereq: None Units: 3-1-8 URL: http://web.mit.edu/7.30j Lecture: TR11-12.30 ( 48-316 ) Recitation: M4 ( 48-316 ) or R4 ( 48-316 ) Fundamentals of ecology, considering Earth as an integrated dynamic system. Coevolution of the biosphere, geosphere, atmosphere and oceans. Introduction to thermodynamics. The Earth's energy budget. Photosynthesis and respiration. The hydrologic, carbon and nitrogen cycles. Flow of energy and materials through ecosystems, regulation of the distribution and abundance of organisms, structure and function of ecosystems. Evolution and natural selection; metabolic diversity; productivity. Trophic dynamics; models of population growth, competition, mutualism and predation. Instruction and practice in oral and written communication provided. 7.012-7.014 recommended. S. W. Chisholm, E. Delong
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7.31 Current Topics in Mammalian Biology: Medical Implications ( ) Prereq: 7.05 , 7.06 , or permission of instructor Units: 4-0-8 URL: http://web.mit.edu/7.31/ Lecture: M3,W3-5 (Whitehead-705) Covers recent advances in mammalian cell and developmental biology with particular emphasis on approaches that utilize mouse genetics. Combines formal lectures on selected topics with readings of original papers which are discussed in class. Major emphasis on the implications of mechanisms of human genetic diseases. Topics include early mammalian development; genomic imprinting; X inactivation; embryonic stem cells; nuclear reprogramming of somatic cells; cell migration; nervous system development; and central nervous system degenerative diseases such as Alzheimer's and Huntington's disease. Enrollment limited to 20. F. Gertler, R. Jaenisch
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