| source MIT (X) |
level |
department Brain and Cognitive Sciences (X) |
9.00 Introduction to Psychology ( ) Prereq: None Units: 4-0-8 Credit cannot also be received for SP.318 A survey of the scientific study of human nature, including how the mind works, and how the brain supports the mind. Topics include the mental and neural bases of perception, emotion, learning, memory, cognition, child development, personality, psychopathology, and social interaction. Consideration of how such knowledge relates to debates about nature and nurture, free will, consciousness, human differences, self and society. Enrollment limited to 300. J. D. Gabrieli
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9.01 Introduction to Neuroscience ( ) Prereq: Physics II (GIR) or permission of instructor Units: 4-0-8 Lecture: MW2.30-4 ( 46-3002 ) Recitation: M EVE (7 PM) ( 26-168 ) or T EVE (7 PM) ( 26-168 ) or W EVE (7 PM) ( 26-168 ) or R EVE (7 PM) ( 26-168 ) or W EVE (7 PM) ( 26-142 ) +final Introduction to the mammalian nervous system, with emphasis on the structure and function of the human brain. Topics include the function of nerve cells, sensory systems, control of movement, learning and memory, and diseases of the brain. H. S. Seung, M. Bear
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9.011 Systems Neuroscience ( ) Prereq: Permission of instructor; admission to BCS graduate program Units: 6-0-12 Lecture: MWF2-4 ( 46-4062 ) +final Survey of principles underlying the structure and function of the nervous system, with a focus on systems approaches. Topics: development of the nervous system and its connections, sensory systems of the brain, the motor system, higher cortical functions, behavioral and cellular analyses of learning and memory. A survey of brain and behavioral studies for first-year graduate students. E. K. Miller, M. Wilson
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9.012 Cognitive Science ( ) Prereq: Permission of instructor Units: 6-0-12 Intensive survey of cognitive science. Topics include visual perception, language, memory, cognitive architecture, learning, reasoning, decision-making, and cognitive development. Topics covered from behavioral, computational, and neural perspectives. E. Gibson, P. Sinha, J. Tenenbaum
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9.013J Cellular and Molecular Neurobiology ( ) (Same subject as 7.68J ) Prereq: 9.011 or permission of instructor Units: 6-0-12 URL: http://web.mit.edu/7.68j/ Major areas of cellular and molecular neurobiology including excitable cells and membranes, ion channels and receptors, synaptic transmission, cell-type determination, neurogenesis, axon guidance, neuronal cell biology, neurotrophin signaling and cell survival, synapse formation and neural plasticity. Includes lectures and exams, and involves presentation and discussion of primary literature. Focuses on major concepts and recent advances in experimental neuroscience. M. Constantine-Paton, L.-H. Tsai, W. Quinn
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9.02 Systems Neuroscience Laboratory ( ) Prereq: 9.01 Units: 2-4-6 Consists of a series of laboratories designed to give students experience with basic techniques for conducting systems neuroscience research. Includes sessions on anatomical, neurophysiological, and data acquisition and analysis techniques, and ways these techniques are used to study nervous system function. Training provided in the art of scientific writing with feedback designed to improve writing skills. Assignments include weekly preparation for lab sessions, two major lab reports and a series of basic computer programming tutorials (MATLAB). Involves the use of experimental animals. Enrollment limited. J. J. DiCarlo, C. I. Moore
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9.03 Neural Basis of Learning and Memory ( ) Prereq: 9.01 Units: 3-0-9 Lecture: MW12.30-2 ( 46-3002 ) Highlights the interplay between cellular and molecular storage mechanisms and the cognitive neuroscience of memory. Emphasis on human and animal models of hippocampal mechanisms and function. Lectures and discussion of papers. M. Wilson, S. Corkin
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9.036 The Visual System ( ) Prereq: Permission of instructor Units: 3-0-6 The organization of the mammalian visual system and the manner in which shape, color, texture, motion, and depth are processed. P. H. Schiller
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9.04 Neural Basis of Vision and Audition ( ) Prereq: 9.01 or permission of instructor Units: 3-0-9 Examines the neural bases of visual and auditory processing for perception and sensorimotor control. Focuses on physiological and anatomical studies of the mammalian nervous system as well as behavioral studies of animals and humans. Studies visual pattern, color and depth perception, auditory responses and speech coding, and spatial localization. P. H. Schiller, M. C. Brown
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9.044J Brain Mechanisms for Hearing and Speech ( ) (Same subject as HST.722J ) Prereq: HST.723 or permission of instructor Units: 4-0-8 TBA. An advanced subject covering anatomical, physiological, behavioral, and computational studies of the central nervous system relevant to speech and hearing. Students learn primarily by discussions of scientific papers on topics of current interest. Recent topics include neural circuits in the auditory brainstem, organization and processing in the auditory cortex, auditory reflexes and descending systems, functional imaging of the human auditory system, quantitive methods for relating neural responses to behavior, speech motor control, and cortical representation of language. M. C. Brown, B. Delgutte, F. Guenther, J. Melcher
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9.05 Neural Basis of Movement ( ) Prereq: 9.01 or permission of instructor Units: 3-0-9 Surveys general principles and specific examples of motor control in biological systems. Emphasizes the neural mechanisms underlying different aspects of movement and movement planning. Covers sensory reception, reflex arcs, spinal cord organization, pattern generators, muscle function, locomotion, eye movement, and cognitive aspects of motor control. Functions of central motor structures, including cerebellum, basal ganglia, and cerebral cortex. Cortical plasticity, motor learning and computational approaches to motor control, and motor disorders are discussed. A. Graybiel, M. Sur, E. Bizzi, C. Moore
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9.07 Statistics for Brain and Cognitive Science ( ) Prereq: Calculus I (GIR) , Calculus II (GIR) ; or permission of instructor Units: 3-0-9 Lecture: MW9.30-11 ( 46-3310 ) +final A survey introduction to statistical reasoning and statistical methods relevant to neuroscience and cognitive science research. Core topics include introductions to probability theory, estimation theory, hypothesis testing, linear models, the generalized linear model, and experimental design. Additional topics chosen from Monte Carlo methods, Bayesian methods, time-series analysis, spectral analysis, and point processes theory. Emphasis on developing a firm conceptual understanding of the statistical paradigm and statistical methods primarily through analyses of actual experimental data. E. N. Brown
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9.073J Statistics for Neuroscience Research ( ) (Same subject as HST.460J ) Prereq: 9.07 or permission of instructor Units: 3-0-9 A survey of statistical methods for neuroscience research. Core topics include introductions to the theory of point processes, the generalized linear model, Monte Carlo methods, Bayesian methods, multivariate methods, time-series analysis, spectral analysis and state-space modeling. Emphasis on developing a firm conceptual understanding of the statistical paradigm and statistical methods primarily through analyses of actual experimental data. E. N. Brown
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9.09J Cellular Neurobiology ( ) (Same subject as 7.29J ) Prereq: 7.05 Units: 4-0-8 Introduction to the structure and function of the nervous system. Emphasizes the cellular properties of neurons and other excitable cells. Includes the structure and biophysical properties of excitable cells, synaptic transmission, neurochemistry, neurodevelopment, integration of information in simple systems, and detection and information coding during sensory transduction. W. G. Quinn, J. T. Littleton
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9.10 Cognitive Neuroscience ( ) Prereq: 9.01 Units: 3-0-9 Explores the cognitive and neural processes that support attention, vision, language, motor control, navigation, and memory. Introduces basic neuroanatomy, functional imaging techniques, and behavioral measures of cognition. Discusses methods by which inferences about the brain bases of cognition are made. Considers evidence from patients with neurological disease (Alzheimer's disease, Parkinson's disease, Huntington's disease, amnesia, and focal lesions from stroke) and from young and older individuals without neurological disease. Students prepare presentations summarizing journal articles and write one research proposal to conduct an experiment on a specific problem in cognitive neuroscience. S. Corkin
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9.110J Molecular Pathology and Cognitive Sequelae of Age-dependent Neurological Disease ( ) (Same subject as 7.92J ) Prereq: 9.011 , 9.013 , or permission of instructor Units: 3-0-9 URL: http://web.mit.edu/7.92j/ Lectures and discussions explore the clinical, cognitive, and cellular-molecular aspects of brain aging processes. Topics include loss of memory and other cognitive capacities in normal aging and neurodegenerative conditions, with an emphasis on Alzheimer's disease and associated mouse models. Other topics include neurodegenerative movement disorders, such as Parkinson's and Huntington's diseases. Based on lectures, readings from the primary literature, and discussions. Students are expected to present topics based on their readings. One written midterm test and one final examination. S. Corkin, L.-H. Tsai
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9.12 Experimental Molecular Neurobiology ( ) Prereq: 9.01 , Biology (GIR) Units: 2-4-6 Open to bcs majors only. Lecture: W1-3 ( 46-5056 ) Lab: LAB: T1-5 OR F9.30-1.30 Experimental techniques in cellular and molecular neurobiology. Designed for students without previous experience in techniques of cellular and molecular biology. Experimental approaches include tissue culture of neuronal cell lines, dissection and culture of brain cells, DNA manipulation, synaptic protein analysis, immunocytochemistry, and fluorescent microscopy. One lab session plus one paper review session per week. Enrollment limited. C. Lois
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9.14 Brain Structure and Its Origins ( ) Prereq: 9.01 Units: 3-0-9 Outline of mammalian functional neuroanatomy, aided by studies of comparative neuroanatomy and evolution, and of brain development. Topics include early steps to a central nervous system, basic patterns of brain and spinal cord connections, regional development and differentiation, regeneration, motor and sensory pathways and structures, systems underlying motivations, innate action patterns, formation of habits, and various cognitive functions. Lab techniques reviewed. Optional brain dissections. G. E. Schneider
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9.15 Biochemistry and Pharmacology of Synaptic Transmission ( ) (Subject meets with 9.150 ) Prereq: 9.01 , 7.05 , or permission of instructor Units: 3-0-9 Lecture: MW12.30-2 ( 46-3310 ) 9.150 Biochemistry and Pharmacology of Synaptic Transmission ( ) (Subject meets with 9.15 ) Prereq: 9.011 or permission of instructor Units: 3-0-6 Lecture: MW12.30-2 ( 46-3310 ) Considers the process of neurotransmission, especially chemicals used in the brain and elsewhere to carry signals from nerve terminals to the structures they innervate. Focuses on monoamine transmitters (acetylcholine; serotonin; dopamine and norepinephrine); also examines amino acid and peptide transmitters and neuromodulators like adenosine. Macromolecules that mediate neurotransmitter synthesis, release, inactivation and receptor-mediated actions are discussed, as well as factors that regulate their activity and the second-messenger systems and ion fluxes that they control. The involvement of particular neurotransmitters in human diseases is considered. R. J. Wurtman, K. Goosens
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9.161 Cellular Neurophysiology ( ) Prereq: 9.011 or permission of instructor Units: 3-0-9 Surveys the mechanisms of neuronal communication. Covers ion channels in excitable membrane, single cell computation, synaptic transmission, and synaptic plasticity. Correlates the properties of ion channels and synaptic transmission with their physiological function. Discusses the organizational principles for the formation of functional neural networks at synaptic and cellular levels. Involves discussion of primary literature. Juniors and seniors require instructor's permission. Staff
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9.173J Noninvasive Imaging in Biology and Medicine ( ) (Same subject as 20.483J , 22.56J , HST.561J ) Prereq: 18.03 , 8.03 , or permission of instructor Units: 3-0-9 Background in the theory and application of noninvasive imaging methods in biology and medicine, with emphasis on neuroimaging. Focuses on the modalities most frequently used in scientific research (x-ray CT, PET/SPECT, MRI, and optical imaging), and includes discussion of molecular imaging approaches used in conjunction with these scanning methods. Lectures are supplemented by in-class discussions of problems in research and demonstrations of imaging systems. A. Jasanoff
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9.18 Developmental Neurobiology ( ) (Subject meets with 7.69J , 9.181J ) Prereq: 9.01 , 7.03 , 7.05 , or permission of instructor Units: 4-0-8 9.181J Developmental Neurobiology ( ) (Same subject as 7.69J ) (Subject meets with 9.18 ) Prereq: 9.011 or permission of instructor Units: 4-0-8 URL: http://web.mit.edu/7.69j/ Considers molecular control of neural specification, formation of neuronal connections, construction of neural systems, and the contributions of experience to shaping brain structure and function. Topics include: neural induction and pattern formation, cell lineage and fate determination, neuronal migration, axon guidance, synapse formation and stabilization, activity-dependent development and critical periods, development of behavior. In addition to final exam, analysis and presentation of research papers required for final grade. Additional readings required for graduate credit. E. Nedivi
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9.20 Animal Behavior ( ) Prereq: 9.00 or permission of instructor Units: 3-0-9 Lecture: MW4 ( 46-3015 ) Recitation: F3 ( 46-3310 ) +final Evolution of behavior, the driver of nervous system evolution, is reviewed emphasizing concepts developed in ethology and sociobiology. Examines foraging and feeding, defensive and aggressive behavior, courtship and reproduction, migration and navigation, and various social activities and communication. Students consider the contributions of inherited patterns and cognitive abilities as well as the roles of various types of plasticity. Both field and laboratory studies are reviewed; human behavior is considered in the context of primate studies. G. E. Schneider
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9.205 Biological Basis of Animal Behavior ( ) Prereq: 9.011 or permission of instructor Units: 2-0-7 Seminar explores the biological basis of animal behavior, focusing on its physiological and genetic mechanisms. Topics include genetic control of cast behavior in ants, navigation control in insects, speciation in cichlids, vocal learning in birds, magnetoreception in birds and mammals, genetic control of sexual preference in mammals, electroreception in fish, and pheromone perception in mammals. Critical reading of the relevant literature and presentations by the students. Limited to 10 students. C. Lois
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9.22J A Clinical Approach to the Human Brain ( ) (Same subject as HST.422J ) Prereq: None Units: 3-0-9 Introduction to normal and abnormal human brain functioning, including the cellular basis of activity-dependent development, critical periods, and plasticity of the brain through learning; neurotransmitters and emotional disorders; fMRI studies of vision, language, dyslexia, motor function, pain, placebo effects, and emotional states. Implications for education, prevention of dementia and dyslexia. Enrollment limited to 25. T. N. Byrne
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