| source University of Toronto, Mississauga (X) |
level |
department Chemistry (X) |
Matter and its transformations are studied at both the microscopic and the macroscopic levels. Topics include atomic and molecular structure, intermolecular forces of attraction and the phases of matter, organic chemical reactions and mechanisms, principles of systems at equilibrium, thermodynamics, electrochemistry and kinetics. [
Score: 8.276823 Details | Listing | Web page
A rigorous introduction to the theory and practice of analytical chemistry. Development and applications of basic statistical concepts in treatment and interpretation of analytical data; direct and indirect precipitations; volumetric methods; acid-base, complexometric, redox and precipitation titrations; introduction to instrumental methods; potentiometry and absorption spectroscopy. Applications in biomedical, forensic and environmental areas will be considered. [
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Equilibrium thermodynamics and its application to ideal and non-ideal systems: internal energy, enthalpy, entropy, free energy, chemical potential, colligative properties, phase rule and phase diagrams. Kinetics: rate laws, activated complex theory, mechanisms, measurement of very fast reaction rates. [
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Atomic structure; periodic properties of the elements; bonding theories-ionic, covalent (valence bond and molecular orbital) and metallic; structure and bonding in coordination compounds of main group elements and transition metals; descriptive chemistry of the metals. Reaction mechanisms. [
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Fundamentals of organic chemistry emphasizing reactions of alkanes and alkenes. The first half of a two-course sequence (with
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The chemistry of benzene, alcohols, aldehydes, ketones, carboxylic acid, esters, acid chlorides, amides and amines will be covered. As well, electrophilic aromatic substitution, protection and deprotection of alcohols, nucleophilic acyl substitution, nucleophilic addition, carbonyl alpha-substitution reaction, keto-enol tautomerism, carbonyl ccondensation and proton NMR will be introduced. The emphasis will be on organic mechanisms and application of organic reactions to multistep synthesis. Continues from
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This courses provides a richly rewarding opportunity for students in their second year to work in the research project of a professor in return for 299Y course credit. Students enrolled have an opportunity to become involved in original research, learn research methods and share in the excitement and discovery of acquiring new knowledge. Participating faculty members post their project descriptions for the following summer and fall/winter sessions in early February and students are invited to apply in early March. See
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Introduction to the basic theory and practice underlying important techniques in analytical chemistry, chosen from three major areas of instrumental analysis: spectroscopy, electrochemistry and separation science. Specific topics will include fluorescence spectroscopy, atomic spectroscopy, x-ray fluorescence, voltammetry, high resolution gas and liquid chromatography, mass spectrometry, and a brief introduction to computer applications, including Fourier transform methods. A problem-based approach will be used to explore these methods in a wide variety of practical applications. [
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Chemistry of metallic elements. Organometallics. Main group and transition elements. Rings, cages and clusters. Lanthanides and Actinides. Applications of IR, UV-VIS and multinuclear NMR spectroscopy. Symmetry. Inorganic synthesis. Non-aqueous solvents. Structure and bonding. Catalysis and industrial processes. [
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Principles of inorganic chemical reactions and their application to biochemical systems: kinetics, mechanisms and thermodynamics of ligand exchange, acid-base and redox reactions involving metalloproteins and their model compounds; mechanisms of catalysis by metalloenzymes and their model compounds; therapeutic uses of coordination complexes. [
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Stereochemistry and conformational analysis; mechanisms of important types of organic reaction; pericyclic reactions; reactive intermediates. [
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Methods used for forming carbon-carbon bonds will be reviewed, including reactions of the various types of nucleophilic carbon and the use of organometallic reagents. Other topics include functional group interconversions, oxidation and reduction and the role of elements such as boron, silicon and tin in organic synthesis. [
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The chemistry of selected classes of naturally occurring molecules such as those below, with emphasis on structure, stereochemistry, properties and synthesis. Amino acids, peptides, proteins, carbohydrates, lipids, nucleosides, nucleotides, and nucleic acids. [
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An introduction to the molecular anatomy and properties of the major cellular biomolecules: proteins, nucleic acids, carbohydrates and lipids. The course also covers the structural organization of membranes and nucleoproteins. Enzyme mechanisms and membrane transport phenomena will be examined in the context of structure/function relationships.
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Basic principles of biological energetics. Metabolic pathways for carbohydrate and lipid synthesis and degradation. Survey of amino acid and nucleotide metabolism. Integration and cellular regulation of metabolism. Intracellular signal transduction mechanisms. [
Score: 8.276823 Details | Listing | Web page
A laboratory course to complement
Score: 8.276823 Details | Listing | Web page
This laboratory course represents an integration of the study of fundamental physical chemistry with wide-ranging applications to instrumental methods of analysis, such as separation science, electrochemistry, spectroscopy and computer methods. The course will provide a solid hands-on grounding in many of the major topics covered in analytical and physical chemistry, and the optimization of instrumental analytical measurements by the application of physical principles. Students select from a variety of instruments to customize their program, and develop their own analytical methods to address analytical problems of interest to the student. [
Score: 8.276823 Details | Listing | Web page
This laboratory course comprises the synthesis of inorganic, organometallic, and organic compounds, supplemented by physical measurements (e.g., ir, uv, ¹H NMR spectra, kinetics, etc.) of the products where appropriate. Approximately eight weeks each will be spent on two groups of core experiments, one in organic and one in inorganic synthesis. The remaining eight to ten weeks will be occupied by a choice of inorganic, organometallic, and/or organic experiments. [
Score: 8.276823 Details | Listing | Web page
This course provides third-year undergraduate students (after completion of at least 8 to 10 credits) who have developed some knowledge of Chemistry and its research methods, an opportunity to work in the research project of a professor in return for course credit. Students enrolled have the opportunity to become involved in original research, enhance their research skills and share in the excitement of acquiring new knowledge and in the discovery process of science. This course does not count as one of the requirements in the Chemistry Minor, Chemistry Major, Chemistry Specialist or Biological Chemistry Specialist programs. Participating faculty members post their project descriptions for the following summer and fall/winter sessions in early February and students are invited to apply in early March. See
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Review of recent and fundamental developments of instrumentation that are revolutionizing the field of analytical chemistry as applied to biological chemistry and biotechnology. Topics will include specialized mass spectrometers, secondary ion mass spectrometry, and the GC/MS and LC/MS interfaces; a survey of surface-oriented techniques including electron spectroscopy, attenuated total reflection methods and photoacoustic spectroscopy; Fourier transform theory and methods; microcomputer communication, instrument interfacing and computational methods of chemometrics. [
Score: 8.276823 Details | Listing | Web page
Separation science will be explored by building on a survey of fundamental physical principles to understand processes of extraction, and technologies such as solid phase microextraction, supercritical fluid extraction, immunoaffinity extraction and molecularly imprinted polymers. Plate and rate theory will be developed to consider various forms of gas and liquid chromatographic methods, including hyphenated techniques that bridge to information detectors such as mass spectrometers. New opportunities for chromatography and separations by movement to small scale size will be considered by focusing on microfluidics, electro-osmotic flow and chip based microdevice applications. Applications examples will focus on problems in life sciences, forensics and environmental chemistry. [
Score: 8.276823 Details | Listing | Web page
Applications of advanced fundamentals to, and recent developments in, multi-step organic synthesis. [
Score: 8.276823 Details | Listing | Web page
An introduction to drug discovery, design and development. This course will focus on the potential of proteins (enzymes, receptors, receptor structure and signal transduction) as targets for molecular therapeutic intervention. The strategies of finding a drug target, optimizing target interactions and synthetic molecular therapeutic development will all be considered and discussed. The modern technologies of targeting protein-protein interactions will also be covered. [
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Survey of recent developments in biological chemistry and applications of chemistry to study processes of biological significance. [
Score: 8.276823 Details | Listing | Web page
Biophysical approaches to studies of protein interactions, structures, and dynamics. Theory and practice of specific experimental approaches will provide a fundamental understanding on information potential and technique limitations. Specific applications from the current literature will be discussed. Student evaluations will include oral presentations describing studies using the techniques. [
Score: 8.276823 Details | Listing | Web page