| source MIT (X) |
level |
department Harvard-MIT Division of Health Sciences and Technology (X) |
HST.011 Human Functional Anatomy ( ) (Subject meets with HST.010 ) Prereq: Permission of instructor Units: 3-11-10 HST.010: Lecture: MWF1.30-6 (BEGINS SEPT 2) ( D AMPH ) Lab: MWF1.30-6 (BEGINS SEPT 2) (MEC 419) HST.011: Lecture: MWF1.30-6 (BEGINS SEPT 2) ( D AMPH ) Lab: MWF1.30-6 (BEGINS SEPT 2) (MEC 419) Lectures, detailed laboratory dissections, and prosections provide a thorough exploration of the gross structure and function of the human body. Fundamental principles of bioengineering are employed to promote analytical approaches to understanding the body's design. The embryology of major organ systems is presented, together with certain references to phylogenetic development, as a basis for comprehending anatomical complexity. Correlation clinics stress both normal and abnormal functions of the body and present evolving knowledge of genes responsible for normal and abnormal anatomy. Lecturers focus on current problems in organ system research. Only HST students may register under HST.010, graded P/D/F. Enrollment restricted to graduate students. L. Gehrke
Score: 11.25052 Details | Listing | Web page
HST.021 Musculoskeletal Pathophysiology ( ) (Subject meets with HST.020 ) Prereq: Permission of Instructor Units: 3-0-3 Growth and development of normal bone and joints, the process of mineralization, the biophysics of bone and response to stress and fracture, calcium and phosphate homeostasis and regulation by parathyroid hormone and vitamin D, and the pathogenesis of metabolic bone diseases and disease of connective tissue, joints, and muscles, with consideration of possible mechanisms and underlying metabolic derangements. Only HST students may register under HST.020, graded P/D/F. Enrollment limited. Open only to medical and graduate students. M. Bouxsein, M. Seton
Score: 11.25052 Details | Listing | Web page
HST.031 Human Pathology ( ) (Subject meets with HST.030 ) Prereq: Permission of instructor; Biology (GIR) , Physics I (GIR) , or Physics II (GIR) Units: 4-4-8 HST.030: Lecture: TR8.30-12.30 (BEGINS SEP 1) (MEC 209) Lab: TR8.30-12.30 (BEGINS SEP 1) (MEC 209) HST.031: Lecture: TR8.30-12.30 (BEGINS SEP 1) (MEC 209) Lab: TR8.30-12.30 (BEGINS SEP 1) (MEC 209) Introduction to the functional structure of normal cells and tissues, pathologic principles of cellular adaptation and injury, inflammation, circulatory disorders, immunologic injury, infection, genetic disorders, and neoplasia in humans. Lectures, conferences emphasizing clinical correlations and contemporary experimental biology. Laboratories with examination of microscopic and gross specimens, and autopsy case studies emphasizing modern pathology practice. Only HST students may register under HST.030, graded P/D/F. Enrollment limited. R. N. Mitchell
Score: 11.25052 Details | Listing | Web page
HST.035 Principles and Practice of Human Pathology ( ) (Subject meets with HST.034 ) Prereq: 7.01 and 7.05 ; or permission of instructor Units: 4-2-10 Provides a comprehensive overview of human pathology with emphasis on mechanisms of disease and modern diagnostic technologies. Topics include general mechanisms of disease (inflammation, infection, immune injury, transplantation, genetic disorders and neoplasia); pathology of lipids, enzymes, and molecular transporters; pathology of major organ systems; and review of diagnostic tools from surgical pathology to non-invasive techniques such as spectroscopy, imaging, and molecular markers of disease. The objectives of this subject are achieved by a set of integrated lectures and laboratories, as well as a student-driven term project leading to a formal presentation on a medical, socioeconomic, or technological issue in human pathology. Only HST students enrolled in specific degree programs may register under HST.034, graded P/D/F. Credit cannot also be received for HST.030 or HST.031. K. Badizadegan, G. Tearney
Score: 11.25052 Details | Listing | Web page
HST.041 Mechanisms of Microbial Pathogenesis ( ) (Subject meets with HST.040 ) Prereq: Biology (GIR) , 7.05 , permission of instructor Units: 3-6-5 HST.040: Lecture: TR8.30-1 (BEGINS SEPT 1) (MEC 250) Lab: TR8.30-1 (BEGINS SEPT 1) (MEC 343) HST.041: Lecture: TR8.30-1 (BEGINS SEPT 1) (MEC 250) Lab: TR8.30-1 (BEGINS SEPT 1) (MEC 343) Deals with the mechanisms of pathogenesis of bacteria, viruses, and other microorganisms. Approach spans mechanisms from molecular to clinical aspects of disease. Topics selected for intrinsic interest and cover the demonstrated spectrum of pathophysiologic mechanisms. Only HST students may register under HST.040, graded P/D/F. Enrollment limited. C. Crumpacker II, H. Simon
Score: 11.25052 Details | Listing | Web page
HST.061 Endocrinology ( ) (Subject meets with HST.060 ) Prereq: Biology (GIR) , 7.05 , permission of instructor Units: 6-0-6 Physiology and pathophysiology of the human endocrine system. Three hours of lecture and section each week concern individual parts of the endocrine system. Topics include assay techniques, physiological integration, etc. At frequent clinic sessions, patients are presented who demonstrate clinical problems considered in the didactic lectures. Only HST students may register under HST.060, graded P/D/F. Enrollment limited. W. Kettyle, A. Goldfine
Score: 11.25052 Details | Listing | Web page
HST.071 Human Reproductive Biology ( ) (Subject meets with HST.070 ) Prereq: Biology (GIR) , 7.05 , permission of instructor Units: 2-4-3 HST.070: Meets 8/31 through 10/21 only. Lecture: MW1-4,F1-3.30 (MEC 209) HST.071: Meets 8/31 through 10/21 only. Lecture: MW1-4,F1-3.30 (MEC 209) Lectures and clinical case discussions designed to provide the student with a clear understanding of the physiology, endocrinology, and pathology of human reproduction. Emphasis is on the role of technology in reproductive science. Suggestions for future research contributions in the field are probed. Students become involved in the wider aspects of reproduction, such as prenatal diagnosis, in vitro fertilization, abortion, menopause, contraception and ethics relation to reproductive science. Only HST students may register under HST.070, graded P/D/F. H. Klapholz
Score: 11.25052 Details | Listing | Web page
HST.081 Hematology ( ) (Subject meets with HST.080 ) Prereq: 7.05 , permission of instructor Units: 3-6-4 An intensive survey of the biology, physiology, and pathophysiology of blood with systematic consideration of hematopoiesis, white blood cells, red blood cells, platelets, coagulation, plasma proteins, and hematologic malignancies. Emphasis given equally to didactic discussion and analysis of clinical problems. Only HST students may register under HST.080, graded P/D/F. Enrollment limited. D. J. Kuter, J. O. Jacobson, J. Bradner, R. Rosovsky
Score: 11.25052 Details | Listing | Web page
HST.091 Cardiovascular Pathophysiology ( ) (Subject meets with HST.090 ) Prereq: HST.030 or HST.031 ; permission of instructor Units: 3-3-9 Normal and pathologic physiology of the heart and vascular system. Emphasis includes hemodynamics, electrophysiology, gross pathology, and clinical correlates of cardiovascular function in normal and in a variety of disease states. Special attention given to congenital, rheumatic, valvular heart disease and cardiomyopathy. Only HST students may register under HST.090, graded P/D/F. Enrollment limited. E. Edelman
Score: 11.25052 Details | Listing | Web page
HST.101 Respiratory Pathophysiology ( ) (Subject meets with HST.100 ) Prereq: Biology (GIR) , 7.05 , Physics I (GIR) , permission of instructor Units: 4-0-8 Lectures, seminars, and laboratories cover the histology, cell biology, and physiological function of the lung with multiple examples related to common diseases of the lung. A quantitative approach to the physics of gases, respiratory mechanics, and gas exchange is provided to explain pathological mechanisms. Use of medical ventilators is discussed in lecture and in laboratory experiences. For MD candidates and other students with background in science. Only HST students may register under HST.100, graded P/D/F. Enrollment limited. J. Drazen, S. Loring, A. Malhotra
Score: 11.25052 Details | Listing | Web page
HST.111 Renal Pathophysiology ( ) (Subject meets with HST.110 ) Prereq: Biology (GIR) , 7.05 , permission of instructor Units: 4-0-8 Considers the normal physiology of the kidney and the pathophysiology of renal disease. Renal regulation of sodium, potassium, acid, and water balance are emphasized as are the mechanism and consequences of renal failure. Included also are the pathology and pathophysiology of clinical renal disorders such as acute and chronic glomerulonephritis, pyelonephritis, and vascular disease. New molecular insights into transporter mutations and renal disease are discussed. Only HST students may register under HST.110, graded P/D/F. Enrollment limited. J. Seifter
Score: 11.25052 Details | Listing | Web page
HST.121 Gastroenterology ( ) (Subject meets with HST.120 ) Prereq: Biology (GIR) , 7.05 , Physics I (GIR) , permission of instructor Units: 3-6-4 HST.120: Lecture: MWF1-4 (BEGINS OCT 23) (MEC 209) HST.121: Lecture: MWF1-4 (BEGINS OCT 23) (MEC 209) Presents the anatomy, physiology, biochemistry, biophysics, and bioengineering of the gastrointestinal tract and associated pancreatic, liver, and biliary systems. Emphasis on the molecular and pathophysiological basis of disease where known. Covers gross and microscopic pathology and clinical aspects. Formal lectures given by core faculty, with some guest lectures by local experts. Selected seminars conducted by students with supervision of faculty. Only HST students may register under HST.120, graded P/D/F. Enrollment limited. M. C. Carey
Score: 11.25052 Details | Listing | Web page
HST.131 Introduction to Neuroscience ( ) (Subject meets with HST.130 ) Prereq: Permission of instructor Units: 6-3-6 HST.130: Lecture: MWF9-12 (BEGINS AUG 31) (MEC 227) HST.131: Lecture: MWF9-12 (BEGINS AUG 31) (MEC 227) A comprehensive introductory course in neuroscience, exploring the brain on levels ranging from molecules and cells through neural systems, perception, memory, and behavior. Some aspects of clinical neuroscience, within neuropharmacology, pathophysiology, and neurology. Lectures are supplemented by conferences and labs. Labs review neuroanatomy at the gross and microscopic levels. Only HST students may register under HST.130, graded P/D/F. Enrollment limited to 50. R. H. Masland
Score: 11.25052 Details | Listing | Web page
HST.140 Molecular Medicine ( ) Prereq: 7.05 Units: 2-0-4 [P/D/F] Lecture: T1-3 (BEGINS SEPT 8) (MEC 447) Conducted as a seminar to study a variety of human diseases and the underlying molecular, genetic, and biochemical basis for the pathogenesis and pathophysiology of the disorders. Lectures by faculty and seminars conducted by students, with tutorials and supervision by faculty. Patients presented when feasible. Appropriate for students who have had a course in biochemistry and/or molecular biology. I. M. London, G. Q. Daley, D. E. Cohen
Score: 11.25052 Details | Listing | Web page
HST.147 Human Biochemistry and Metabolic Diseases ( ) (Subject meets with HST.146 ) Prereq: Permission of instructor Units: 3-0-3 First-year graduate level intensive subject in human biochemistry and physiological chemistry that focuses on intermediary metabolism, structures of key intermediates and enzymes important in human disease. Subject is divided into four areas: carbohydrates, lipids, amino acids and nucleic acids. The importance of these areas is underscored with examples from diseases and clinical correlations that are introduced by clinician-scientists. Only HST students may register under HST.146, graded P/D/F. Enrollment limited. D.T. McLaughlin, C. N. Serhan
Score: 11.25052 Details | Listing | Web page
HST.151 Principles of Pharmacology ( ) (Subject meets with HST.150 ) Prereq: Biology (GIR) , 7.05 , Physics I (GIR) Units: 3-0-9 An introduction to pharmacology. Topics include mechanisms of drug action, dose-response relations, pharmacokinetics, drug delivery systems, drug metabolism, toxicity of pharmacological agents, drug interactions, and substance abuse. Selected agents and classes of agents examined in detail. BEP students must register for HST.151 (graded) other HST students may register under HST.150 (P/D/F). Course follows HMS calendar. Restricted to HST MD, HST MEMP or HST BEP students. C. Rosow, G. Forman, G. Strichartz
Score: 11.25052 Details | Listing | Web page
HST.161 Molecular Biology and Genetics in Modern Medicine ( ) (Subject meets with HST.160 ) Prereq: Biology (GIR) , 7.05 Units: 6-0-6 HST.160: Lecture: T2-5 (BEGINS SEPT 4) ( E52-175 ) Lab: F9.30-12.30 (MEC 209) HST.161: Lecture: T2-5 (BEGINS SEPT 4) ( E52-175 ) Lab: F9.30-12.30 (MEC 209) Foundation for understanding the relationship between molecular biology, developmental biology, genetics, genomics, bioinformatics, and medicine. Develops explicit connections between basic research, medical understanding, and the perspective of patients. Principles of human genetics reviewed. Translation of clinical understanding into analysis at the level of the gene, chromosome and molecule; the concepts and techniques of molecular biology and genomics; and the strategies and methods of genetic analysis, including an introduction to bioinformatics. Extends beyond basic principles to current research activity in human genetics. Only HST students may register under HST.160, graded P/D/F. A. Giersch, D. Housman
Score: 11.25052 Details | Listing | Web page
HST.176 Cellular and Molecular Immunology ( ) (Subject meets with HST.175 ) Prereq: 7.05 Units: 4-0-8 HST.175: Lecture: MW9-12 (BEGINS AUG 31) (MEC 209) HST.176: Lecture: MW9-12 (BEGINS AUG 31) (MEC 209) Covers cells and tissues of the immune system, lymphocyte development, the structure and function of antigen receptors, the cell biology of antigen processing and presentation including molecular structure and assembly of MHC molecules, lymphocyte activation, the biology of cytokines, leukocyte-endothelial interactions, and the pathogenesis of immunologically mediated diseases. Consists of lectures and tutorials in which clinical cases are discussed with faculty tutors. Details of each case covering a number of immunological issues in the context of disease are posted on a student website. Sections are integrated with HST.031. Only HST students may register under HST.175, graded P/D/F. Enrollment limited to 45. S. Pillai
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HST.186 Special Subjects in Health Sciences and Technology ( , , , ) Prereq: None Units arranged [P/D/F] Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. J. E. Greenberg
Score: 11.25052 Details | Listing | Web page
HST.187 Special Subjects in Health Sciences and Technology ( , , , ) Prereq: None Units arranged [P/D/F] TBA. Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. J. E. Greenberg
Score: 11.25052 Details | Listing | Web page
HST.188 Special Subjects in Health Sciences and Technology ( , , , ) Prereq: Permission of instructor Units arranged Lecture: R1.30-3.30 ( 14E-310 ) Opportunity for group study of advanced subjects related to Health Sciences and Technology not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. J. E. Greenberg
Score: 11.25052 Details | Listing | Web page
HST.189 Special Subjects in Health Sciences and Technology ( , , , ) Prereq: Permission of instructor Units arranged TBA. Opportunity for group study of advanced subjects related to health sciences and technology not otherwise included in the curriculum. Offerings are initiated by HST faculty on an ad hoc basis subject to program approval. Prerequisites may vary by topic; consult faculty at time of offering. J. Greenberg
Score: 11.25052 Details | Listing | Web page
HST.191 Introduction to Biostatistics and Epidemiology ( ) (Subject meets with HST.190 ) Prereq: Calculus II (GIR) Units: 3-0-3 Fundamentals of biostatistics and epidemiology. Trains students how to comprehend, critique and communicate findings from biomedical literature. How to assess the importance of chance in the interpretation of experimental data. Topics include probability theory, normal sampling, chi-squared and t-tests, analysis of variance, linear regression and survival analysis, as well has how to perform elementary calculations using the statistical package STATA. How to identify and prevent bias in observational studies. Causal inference, types of bias (confounding, selection and information bias), key study designs (randomized trials, cohort and case-control studies, and screening programs). Only HST students may register under HST.190, graded P/D/F. Enrollment limited; restricted to medical and graduate students. R. Betensky, M. Hernan
Score: 11.25052 Details | Listing | Web page
HST.196 Teaching Health Sciences and Technology ( , , , ) Prereq: None Units arranged [P/D/F] TBA. For teaching assistants in HST where the teaching assignment is approved for academic credit by the department. J. V. Bonventre, M. L. Gray
Score: 11.25052 Details | Listing | Web page
HST.198 Special Topics in Health Sciences and Technology ( , , , ) Prereq: Permission of instructor Units arranged TBA. Opportunity for study of topics related to HST but not included elsewhere in the catalog. Registration under this subject normally used for situations involving individual study under supervision of a faculty member, but may, when appropriate, be used for small study groups. Normal registration is for 12 units. J. Greenberg
Score: 11.25052 Details | Listing | Web page