For course description, see Social Science.
Score: 6.3095536 Details | Listing | Web page
General principles of the function and organization of nervous systems, providing both an overview of the subject and a foundation for advanced courses. Topics include the physical and chemical bases for action potentials, synaptic transmission, and sensory transduction; anatomy; development; sensory and motor pathways; memory and learning at the molecular, cellular, and systems level; and the neuroscience of brain diseases. Instructors: Adolphs, Kennedy, Lester.
Score: 6.3095536 Details | Listing | Web page
Introduction to the neurobiological study of natural behavior of animals. Topics include such questions as how animals recognize and localize signals in their natural environments, how animals move, how behavior develops, what and how animals learn, and how natural selection shapes the evolution of brain and behavior. Instructor: Konishi.
Score: 6.3095536 Details | Listing | Web page
A lecture and discussion course on the neurobiology of behavior. Topics may include biological clocks, eating behavior, sexual behavior, addiction, mental illness, and neurodegenerative diseases. Instructor: Patterson. Given in alternate years; not offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
An introduction to the comparative study of the gross and microscopic structure of nervous systems. Emphasis on the vertebrate nervous system; also, the highly developed central nervous systems found in arthropods and cephalopods. Variation in nervous system structure with function and with behavioral and ecological specializations and the evolution of the vertebrate brain. Instructor: Allman. Given in alternate years; offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
An integrative approach to the study of vertebrate evolution combining comparative anatomical, behavioral, embryological, genetic, paleontological, and physiological findings. Special emphasis will be given to: (1) the modification of developmental programs in evolution; (2) homeostatic systems for temperature regulation; (3) changes in the life cycle governing longevity and death; (4) the evolution of brain and behavior. Instructor: Allman. Given in alternate years; not offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
For course description, see Environmental Science and Engineering.
Score: 6.3095536 Details | Listing | Web page
For course description, see Environmental Science and Engineering.
Score: 6.3095536 Details | Listing | Web page
For course description, see Biochemistry and Molecular Biophysics.
Score: 6.3095536 Details | Listing | Web page
For course description, see Computation and Neural Systems.
Score: 6.3095536 Details | Listing | Web page
Lectures and discussions on the underlying principles behind digital, video, differential interference contrast, phase contrast, confocal, and two-photon microscopy. The course will begin with basic geometric optics, characteristics of lenses and microscopes, and principles of accurate imaging. Specific attention will be given to how different imaging elements such as filters, detectors, and objective lenses contribute to the final image. Course work will include critical evaluation of published images and design strategies for simple optical systems. Emphasis in the second half of the course will be placed on the analysis and presentation of two- and three-dimensional images. No prior knowledge of microscopy will be assumed. Instructor: Fraser.
Score: 6.3095536 Details | Listing | Web page
For course description, see Computation and Neural Systems.
Score: 6.3095536 Details | Listing | Web page
An introduction to current molecular genetic techniques including basic microbiological procedures, transposon and UV mutagenesis, gene transfer, preparation of DNA, restriction, ligation, electrophoresis (including pulsed-field), electroporation, Southern blotting, PCR, gene cloning, sequencing, and computer searches for homologies. The first half of the course involves structured experiments designed to demonstrate the various techniques. The second half is devoted to individual research projects in which the techniques are applied to original studies on an interesting, but not well studied, organism. Graded pass/fail. Instructor: Bertani.
Score: 6.3095536 Details | Listing | Web page
Lectures on and discussion of the regulatory genome; phylogenetic relationships in animals and the fossil record; how developmental gene regulation works; regulatory basis of development in the simplest systems; making parts of the adult animal body plan; pattern formation and deep regulatory networks; the Precambrian world and a gene-regulatory view of the evolutionary origin of animal forms; processes of
Score: 6.3095536 Details | Listing | Web page
For course description, see Computation and Neural Systems.
Score: 6.3095536 Details | Listing | Web page
For course description, see Computation and Neural Systems.
Score: 6.3095536 Details | Listing | Web page
Introduction to the genetics of humans. Subjects covered include human genome structure, genetic diseases and predispositions, the human genome project, forensic use of human genetic markers, human variability, and human evolution. Given in alternate years; offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
The course covers the mechanisms by which eukaryotic cells control their duplication. Emphasis will be placed on the biochemical processes that ensure that cells undergo the key events of the cell cycle in a properly regulated manner. Instructor: Dunphy.
Score: 6.3095536 Details | Listing | Web page
For course description, see Computer Science.
Score: 6.3095536 Details | Listing | Web page
This course will cover the cellular and molecular basis of diseases of the nervous system, as well as current and future therapeutic approaches. These diseases include disorders of abnormal protein structure (Alzheimer’s, Huntington’s, Parkinson’s, prion), autoimmunity (multiple sclerosis), and developmental disorders of cognition and social communication (schizophrenia, autism). Genetic and environmental etiologies will be explored, and animal models will be compared to the human condition. The role of the reward system in addiction will also be discussed. Instructor: Patterson. Given in alternate years; offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
A seminar about developmental gene regulatory networks (GRNs). It is specifically directed at the gene regulatory networks that control animal development as distinct from any prokaryote or yeast gene networks, or reversible physiological networks of complex organisms. Instructor: Davidson. Given in alternate years; offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
In-depth reviews of the current understanding of the ubiquitin system, a large set of regulatory pathways that mediate a remarkably broad range of cellular and metacellular (organismal) functions. Both proteolytic and nonproteolytic roles of the ubiquitin system will be addressed. Other proteolytic pathways, such as the autophagy, the blood clotting cascade, and the complement system will also be reviewed. Graded pass/fail. Instructor: Varshavsky.
Score: 6.3095536 Details | Listing | Web page
An advanced course with lectures and seminar presentations, based on reading from the current literature. The characteristics of blood cells offer unique insights into the molecular basis of lineage commitment and the mechanisms that control the production of diverse cell types from pluripotent precursors. The course will cover the nature of stem cells, the lineage relationships among differentiated cell types, the role of cytokines and cytokine receptors, apoptosis and lineage-specific proliferation, and how differentiation works at the level of gene regulation and regulatory networks. Roles of prominent regulatory molecules in hematopoietic development will be compared with their roles in other developmental systems. Emphasis will be on explanation of cellular and system-level phenomena in terms of molecular mechanisms. Instructor: Rothenberg. Given in alternate years; not offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
Topics include early embryonic development in various organisms, culture of embryonic stem cells (SCs) as well as adult SCs from various tissues, the therapeutic uses of SCs and current clinical trials, tissue engineering, gene therapy for SC modification, imaging techniques, and SCs in cancer and aging. Instructor: Patterson.
Score: 6.3095536 Details | Listing | Web page
A course of lectures, readings, and discussions focused on the genetic, physiological, and ecological bases of behavior in mammals. A basic knowledge of neuroanatomy and neurophysiology is desirable. Instructor: Allman. Given in alternate years; not offered 2008–09.
Score: 6.3095536 Details | Listing | Web page
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