4.255J Site and Urban Systems Planning ( ) (Same subject as 11.304J ) Prereq: Permission of instructor Units: 2-2-8 Land inventory, analysis and the planning of sites and the infrastructure systems which serve them. Spatial organization of uses, parcalization, design of roadways, grading, utility systems, stormwater runoff, parking, traffic and off-site impacts, landscaping. Lectures on analytical techniques and examples of good site-planning practice. Assignments and a client based project. E. Ben-Joseph
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4.257J Property Rights in Transition ( ) (Same subject as 11.467J , 17.550J ) Prereq: Permission of instructor Units: 3-0-9 Focuses on the property rights debates and conflicts that undergird many planning and development issues. Topics include their justification, ownership, norms and informal rights, institutions and formal rights, their role and externalities in the economy, takings and eminent domain. Uses international case studies as well as concepts of property rights from economic, political, legal and sociological perspectives. A. M. Kim
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4.259 Special Problems in Urban Design ( , ) Prereq: Permission of instructor Units arranged Consult instructor Supplementary work on individual or group basis. Registration subject to prior arrangement for subject matter and supervision by staff. J. Beinart, M. Dennis, A. D'Hooghe
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4.260J Asia Modern: Architecture and Urbanism (New) ( ) (Same subject as 11.336J ) Prereq: None Units: 3-0-9 Seminar examines the advent of modernism in Asia and its emergent manifestations in architecture and urbanism. Theoretical writings, built work and case studies of architectural practices in the region serve as the basis for examining and understanding the contemporary architectural and urban landscapes of Asia. Critical discussion of themes such as notions of modernity, critical regionalism, vernacularism, tropicalism, counter-modernity, nationalism, and issues of architectural identity. Also covers issues related to emergent urban landscapes in Asia, including informal urbanism and sustainability, and addressees questions about historic preservation. R. Mehrotra
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4.262J Ideal Forms of Contemporary Urbanism ( ) (Same subject as 11.311J ) Prereq: 4.645 , 4.241J , 11.330J or permission of instructor Units arranged Lecture: W EVE (6-9 PM) ( 10-401 ) Advanced seminar about an architectural approach to the problems of disurbanization. Focuses on texts and projects of a particular lineage of architects and planners, who are pursuing 'metropolitan urbanity' through a series of concrete, discrete, tangible interventions from 1944 to 1999. Studies the organization of flows and the articulation of public spaces within various projects seeking a definition of "urbanity" using analytical diagrams. Relates this architectural definition to more theoretical definitions in philosophy and anthropology. A. D'Hooghe
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4.264J Advanced Seminar in Landscape & Urbanism (New) ( ) (Same subject as 11.334J ) Prereq: Permission of instructor Units: 3-0-9 Explores the relationships between landscape and urbanism, and the theories, tactics and workings of the emerging field of landscape urbanism. Conceives of the field as an intellectual realignment of landscape's role in urbanization processes, rather than qualifying it as a practice-based discipline conditioned by the study of historical precedents and contemporary built projects. Weekly lectures, readings, and guest speakers present a wide array of multi-disciplinary topics. Students conduct independent research which identifies future work for the field. Topics vary from year to year. A. Berger
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4.278 Special Problems in Theory in Architecture ( , ) Prereq: Permission of instructor Units arranged Consult instructor Supplementary work on individual or group basis. Registration subject to prior arrangement for subject matter and supervision by staff. Staff
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4.280 Undergraduate Architecture Internship ( ) Prereq: 4.114 Units: 0-0-6 [P/D/F] Work in an architect's office to gain experience, improve skills, and see the inner workings of an everyday architectural practice. Internships in all sizes of firms and in public and nonprofit agencies. Internships require full-time work for the entire IAP. N. Correa Mehrotra
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4.285, 4.286 Research Topics in Architecture Studies ( , ) Prereq: Permission of instructor Units arranged URL: http://architecture.mit.edu/subjects/fa08/4286.html 4.285: Consult instructor 4.286: Consult instructor Individual or group research. Registration subject to prior arrangement for subject matter and supervision by staff. J. Wescoat
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4.287 Graduate Architecture Internship ( ) Prereq: 4.123 Units: 0-0-6 [P/D/F] Work in an architect's office to gain experience, improve skills, and see the inner workings of an everyday architectural practice. Internships in all sizes of firms and in public and nonprofit agencies. Internships require full-time work for the entire IAP. N. Correa Mehrotra
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4.288 Preparation for SMArchS Thesis ( , , ) Prereq: 4.290 Units arranged [P/D/F] Lecture: F2-5 ( 9-255 ) Students select thesis topic, define method of approach, and prepare thesis proposal for SMArchS degree. Faculty supervision on an individual or group basis. Intended for SMArchS program students prior to registration for 4.ThG. Staff
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4.290 S.M.Arch.S. Pre-Thesis Preparation ( ) Prereq: 4.221 or permission of instructor Units arranged [P/D/F] Consult instructor Preliminary work in preparation for the thesis for the SMArchS degree. Supervised by faculty on an individual or group basis. Intended for second term SMArchS program students prior to registration for subject 4.288. Staff
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4.291 Special Problems in Architecture Studies ( , ) Prereq: Permission of instructor Units arranged Consult instructor 4.292, 4.293 Special Problems in Architecture Studies ( , , ) Prereq: Permission of instructor Units arranged [P/D/F] 4.292: Consult instructor 4.293: Consult instructor 4.294 Special Problems in Architecture Studies ( , ) Prereq: Permission of instructor Units arranged [P/D/F] Consult instructor 4.295-4.297 Special Problems in Architecture Studies ( , ) Prereq: Permission of instructor Units arranged URL: http://architecture.mit.edu/subjects/fa08/4297.html 4.295: Consult instructor 4.296: TBA. 4.297: Consult instructor 4.298-4.299 Special Problems in Architecture Studies ( , , ) Prereq: Permission of instructor Units arranged [P/D/F] 4.298: Consult instructor 4.299: Consult instructor Supplementary work on individual or group basis. Registration subject to prior arrangement for subject matter and supervision by staff. C. Ulmann
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20.020 Introduction to Biological Engineering Design ( ) Prereq: None Units: 3-3-3 A project-based introduction to the engineering of synthetic biological systems. Throughout the term, students develop projects that are responsive to real-world problems of their choosing, and whose solutions depend on biological technologies. Lectures, discussions, and studio exercises will introduce (1) components and control of prokaryotic and eukaryotic behavior, (2) DNA synthesis, standards, and abstraction in biological engineering, and (3) issues of human practice, including biological safety; security; ownership, sharing, and innovation; and ethics. Preference to freshmen. N. Kuldell
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20.102 Macroepidemiology and Population Genetics ( ) (Subject meets with 20.215 ) Prereq: Calculus I (GIR) Units: 3-0-9 Lecture: TR1-2.30 ( 56-614 ) Analyses of major causes of mortality in the US since 1900: cancer, cardiovascular and cerebrovascular diseases, diabetes, infectious diseases. Analytical models to derive estimates for historically variant population risk factors and physiological rate parameters. Analysis of familial data to separately estimate inherited and environmental risks. Basic population genetics of dominant, recessive, and non-deleterious inherited risk factors. W. G. Thilly
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20.104J Environmental Risks for Common Disease ( ) (Same subject as 1.081J , ESD.053J ) Prereq: Biology (GIR) , Chemistry (GIR) Units: 3-0-9 Analysis of potentially important risk factors for common diseases in the general environment and the workplace: air-, food- and water-borne chemicals; subclinical infections; diet and lifestyle choices. Analysis of history of changes in common disease rates. General paradigm of environmental sources and exposure of human subpopulations, uptake, internal distribution and metabolism of xenobiotics. Measurement of xenobiotic chemicals and allobiotic life forms in human tissues. Potential pathways of induced pathogenesis: mutagenesis, inflammation, hormonal mimicry. W. Thilly, R. McCunney
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20.106J Systems Microbiology ( ) (Same subject as 1.084J ) Prereq: Chemistry (GIR) , Biology (GIR) Units: 3-0-9 Introductory microbiology from a systems perspective. Considers microbial diversity, population dynamics, and genomics. Emphasize the delicate balance between microbes and humans, and changes that result in the emergence of infectious diseases and antimicrobial resistance. Case study approach covers topics such as vaccines, toxins, biodefense, and infections including Legionnaire's disease, tuberculosis, Helicobacter pylori, and plague. D. B. Schauer, E. DeLong
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20.109 Laboratory Fundamentals in Biological Engineering ( , ) Prereq: Biology (GIR) , Chemistry (GIR) , 6.00 , 18.03 ; 20.110 or 20.111 Units: 2-8-5 Lecture: TR11 ( 66-144 ) Lab: TR1-5 ( 56-322 ) or WF1-5 ( 56-322 ) Introduces experimental biochemical and molecular techniques from a quantitative engineering perspective. Experimental design, data analysis, and scientific communication form the underpinnings of this subject. Examples of discovery-based experimental modules include: DNA Engineering in which students design, construct, and use genetic material; Parts Engineering, which emphasizes protein design and quantitative assessment of protein performance; Systems Engineering, in which students consider genome-wide consequences of genetic perturbations; and Biomaterials Engineering, in which students use biologically-encoded devices to design and build materials. Limited enrollment; priority to BE majors. Fall: A. Belcher, N. Kuldell, B. P. Engelward Spring: A. Jasanoff, J. Niles, A. Stachowiak
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20.110J Thermodynamics of Biomolecular Systems ( ) (Same subject as 2.772J ) Prereq: Calculus II (GIR) , Chemistry (GIR) Units: 5-0-7 Credit cannot also be received for 7.10 Lecture: MWF10 ( 10-250 ) Recitation: TR9 ( 4-159 ) or TR10 ( 4-159 ) or TR1 ( 4-159 ) or TR4 ( 4-159 ) +final Equilibrium properties of macroscopic and microscopic systems. Basic thermodynamics: state of a system, state variables. Work, heat, first law of thermodynamics, thermochemistry. Second and third law of thermodynamics: entropy and its statistical basis, Gibbs function. Chemical equilibrium of reactions in gas and solution phase. Macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding cooperativity, solvation, titration of macromolecules. L. G. Griffith, K. Hamad-Schifferli
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20.111J Physical Chemistry of Biomolecular Systems ( ) (Same subject as 7.10J ) Prereq: Calculus II (GIR) , Chemistry (GIR) , Physics I (GIR) ; Coreq: Physics II (GIR) Units: 5-0-7 Provides a quantitative approach to understanding the physical and chemical laws that govern the behavior of biological macromolecules. Basic thermodynamics, state of a system, state variables. Work, heat, first, second, and third laws of thermodynamics. Entropy and its statistical basis, free energy representations, Legendre transforms, Maxwell relations, Gibbs function, Boltzmann distribution and partition functions. Equilibrium properties of macroscopic and microscopic systems; macromolecular structure and interactions in solution. Driving forces for molecular self-assembly. Binding, cooperativity, solvation, and titration of macromolecules. Applications of introductory quantum mechanics to spectroscopy. Staff
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20.200 Biological Engineering Seminar ( , ) Prereq: Open only to BE graduate students, or by permission of instructor Units: 1-0-2 [P/D/F] Lecture: F12 ( 56-614 ) Weekly one-hour seminars covering graduate student research and presentations by invited speakers. J. S. Wishnok
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20.201 Mechanisms of Drug Actions ( ) Prereq: Permission of instructor Units: 4-0-8 Lecture: MW1.30-3 ( 56-614 ) Recitation: F1.30 ( 56-614 ) Chemical and biological analysis of the metabolism and distribution of drugs and chemicals in animals and humans, and the mechanisms by which they cause therapeutic and toxic responses. Metabolism, pharmacology and toxicity as a basis for drug development. Group project analysis of specific drugs and their role in the market. P. C. Dedon, S. R. Tannenbaum
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20.202 In vivo models: Principles and Practices ( ) Prereq: Permission of instructor Units: 1-1-4 Selected aspects of anatomy, histology, immuno-cytochemistry, in situ hybridization, physiology, and cell biology of mammalian organisms and their pathogens. Subject material integrated with principles of toxicology, in vivo genetic engineering, and molecular biology. A lab/demonstration period each week involves experiments in anatomy (in vivo), physiology, and microscopy to augment the lectures. Offered first half of spring term. J. G. Fox, B. Marini, M. Whary
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20.213 DNA Damage and Genomic Instability ( ) Prereq: 5.07 , 7.05 , permission of instructor Units: 4-0-8 Recent progress has resulted in the identification of dozens of genes that, when mutated, promote tumorigenesis. However, it is not yet clear what causes these mutations. Subject analyzes the chemistry of DNA damaging agents, and continues with analysis of the mutagenic and toxic consequences of modifications to DNA structure. The contrasting perspective that normal DNA processing leads to mutations is also presented. The biochemistry and molecular mechanisms of DNA replication, DNA repair, and recombination form the foundation of the subject. P. C. Dedon, B. P. Engelward
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20.215 Epidemiology, Population Genetics and Cell Biology of Human Cancers ( ) (Subject meets with 20.102 ) Prereq: Calculus II (GIR) , 1.00 Units: 3-0-15 Lecture: TR1-2.30 ( 56-614 ) Logic and technology needed to discover genetic and environmental causes and accelerating factors for common human cancers. Analyses of large organized historical public health databases using quantitative carcinogenesis cascade models. Java-based model construction for mono- and multi-genic inherited risk for late onset (sporadic) cancers. Analyses of historical and clinical data to define role of environmental risk factors. Graduate students complete additional work. W. G. Thilly
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