Drug discovery is an emerging science available to academic investigators. This course provides an overview of these drug discovery techniques, including high through-put screening, cell-based screening, computational methods of lead compound discovery, and chemical methods of optimization.
Score: 5.4045453 Details | Listing | Web page
A combination of lecture and lab exercises presented by the faculty of the Group in Biomedical Sciences, designed to introduce biomedical science graduate students to the essential techniques employed in molecular and cellular pharmacology.
Score: 5.4045453 Details | Listing | Web page
This course is essentially biophysical pharmacology. Two-thirds will be didactic, covering protein structure, thermodynamic stability, receptor-ligand binding, enzyme kinetics, biophysical methods, visualization of structures/docking, mathematical analysis of data. The last section will involve student presentations of topics in biophysical pharmacology.
Score: 5.4045453 Details | Listing | Web page
A selection of short courses in the biomedical and pharmacological sciences offered by resident experts. Topics will vary annually. Each short course will last one to two weeks, meeting five hours a week.
Score: 5.4045453 Details | Listing | Web page
Strategies such as positron emission tomography, magnetic resonance imaging, and ultrasound for nondestructively imaging molecular and cell biological events inside living animals and eventually human patients. Emphasis on detecting angiogenesis, apoptosis, and expression of tumor-specific genes.
Score: 5.4045453 Details | Listing | Web page
Replication cycle and gene regulation of HIV. Molecular approaches to therapy and vaccines.
Score: 5.4045453 Details | Listing | Web page
The course is designed to introduce or reintroduce histology and histopathology of the various organ systems to those who need to analyze mouse tissues as an essential part of their research.
Score: 5.4045453 Details | Listing | Web page
The pharmacogenetics course is designed to introduce graduate students, medical students, and pharmacy students to this emerging area of interest, indicting how hereditary mechanisms influence drug responses in humans. The lectures, examples, discussions, and journal presentations will provide the students with a working knowledge of the domains of pharmacology, how heredity influences any response traits, and the ways that advances in genome technologies support our emerging understanding of how polymorphic genetic variants determine inter-individual differences in drug responses. The course will include lectures, discussions, and journal article presentations by students.
Score: 5.4045453 Details | Listing | Web page
This course will focus on critical reading and understanding current areas in cell and molecular biology. The exact topic will vary, but will include such topics as protein trafficking, cell division, intracellular movement, cell interaction, and cell cycle.
Score: 5.4045453 Details | Listing | Web page
Intended for graduate students interested in principles of classical and molecular genetics. Will attend weekly genetics seminar and participate in didactic/discussion preparatory session.
Score: 5.4045453 Details | Listing | Web page
Informal presentations on topics of current interest in glycobiology as represented in the current scientific literature.
Score: 5.4045453 Details | Listing | Web page
This course will examine the basic principles of genetics and genomics. We will focus on classic discoveries and examples of approaches to current experimental problems. Emphasis areas will vary but general topics include Mendelian inheritance, imprinting, cytogenetics, genome structure, genetic variation, linkage and recombination, complex traits, statistical genetics, population genetics, genomic tools and methodology, medical genetics, model organisms.
Score: 5.4045453 Details | Listing | Web page
This course will examine the innate and adaptive immune responses of humans to microbial infection. In parallel, we will explore the virulence mechanisms through which certain medically important viruses, bacteria, fungi, and parasites subvert host defense to produce infectious disease. Emphasis will be placed on basic molecular genetic and cellular approaches to understanding microbial pathogenesis and host susceptibility, including progress toward novel antibiotic and immune stimulatory therapies.
Score: 5.4045453 Details | Listing | Web page
This course will examine the basic principles of molecular and cellular biology and their impact on medicine focusing on classic discoveries and examples of approaches to current experimental problems. Emphasis areas will vary but will include genes and genomics, chromosome biology and nuclear structure, transcriptional regulation, RNA processing, cell cycle control, cell growth and death, cell differentiation and stem cell biology, molecular motors and motility, membrane trafficking and signaling.
Score: 5.4045453 Details | Listing | Web page
Examines physiological and pathological basis for diseases by exploring normal and dysregulated molecular mechansisms controlling tissue and organ functions. Considers how alterations can be translated into therapeautic interventions and probe unexplored questions regarding human disease etiology and novel drug targets.
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This course will cover most of today’s key aspects in the organization and dynamics of the immune system and its regulation. It will provide students with a basis for understanding the physiology and functioning of the immune system in normal and pathological states.
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An overview of neurophysiological systems, emphasizing mammalian neurophysiology and related model vertebrate systems and concepts. (W)
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Lectures on the molecular and cellular mechanisms of pathogenesis. Topics will include Alzheimer’s disease, cell surface and unclear receptors in disease, signal transduction by oncogenes in cancer cells, AIDS, human diseases affecting glycosylation pathways, rheumatoid arthritis, and arteriosclerosis.
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Molecular and cellular mechanisms underlie the actions of environmental toxicants. This course will investigate approaches to study the impact of environmental toxicants on human health. Other modern approaches that are being implemented to detect and remediate environmental toxicants will also be examined. BGGN 256, BIOM 266 and Chem. 266 students will be required to complete an additional paper and/or exam beyond that expected of students in Chem. 166 and BIMM 166.
Score: 5.4045453 Details | Listing | Web page
This course includes attendance at seminars in genetics and is designed to provoke critical discussion of the presented findings and scientific approaches in a small group setting.
Score: 5.4045453 Details | Listing | Web page
This course includes attendance at seminars in microbiology and is designed to provoke critical discussion of the presented findings and scientific approaches in a small group setting.
Score: 5.4045453 Details | Listing | Web page
This course includes attendance at seminars in molecular and cell biology and is designed to provoke critical discussion of the presented findings and scientific approaches in a small group setting.
Score: 5.4045453 Details | Listing | Web page
This course includes attendance at seminars in pharmacology and is designed to provoke critical discussion of the presented findings and the scientific approaches in a small group setting.
Score: 5.4045453 Details | Listing | Web page
This course includes attendance at seminars in physiology and is designed to provoke critical discussion of the presented findings and scientific approaches in a small group setting.
Score: 5.4045453 Details | Listing | Web page
Topics covered in this course include molecular and cellular mechanisms of viral, bacterial, and protozoan pathogenesis. Host response and microbial mechanisms of evasion of host defense will also be discussed. Sessions will consist of faculty and student presentations of current literature.
Score: 5.4045453 Details | Listing | Web page
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