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University of Toronto, Mississauga - Phylogenetic Principles

Lectures will provide an in-depth coverage of modern methods of phylogenetic reconstruction including molecular systematics based on DNA sequences. The principles and philosophy of classification will be taught with an emphasis on 'tree-thinking', one of the most important conceptual advances in evolutionary biology. Tutorials will focus on recent developments in the study of evolutionary patterns while gaining proficiency in reading, presenting, and critiquing scientific papers. [
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University of Toronto, Mississauga - Conservation and Biodiversity

Biodiversity is the sum of species diversity, and also the interaction of species at population, at ecosystem and at migration-route levels; it is one barometer of environmental health. Conservation biology applies ecological and genetic principles to the problem of declining biodiversity. We discuss the species concept, quantification and cost-benefit analysis of biodiversity and extinction, causes, consequence, diagnosis and treatment of population declines, as well as the effects of different land uses on biodiversity and reserve design. A key part of this course is a case study by each student. [
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University of Toronto, Mississauga - Molecular Biology of Gene Expression and Cancer

The first part of the course examines how genes are regulated in eukaryotic cells. It also explores the field of functional genomics and in particular examines how gene expression can be monitored on a genome-wide basis using DNA microarrays. The second part of the course examines the molecular and genetic basis of cancer including the role of oncogenes, tumor suppressor genes and cell cycle regulating proteins in the development of this disease. Lectures and seminars involve presentation and discussion of recently published research articles. [
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University of Toronto, Mississauga - Functional Genomics and Bioinformatics

Functional Genomics utilizes a variety of modern technologies to understand the molecular, biochemical, cellular and/or physiological function of every gene in an organism's genome. Functional Genomics includes fields of study such as bioinformatics, transcriptomics, and proteomics. Lectures and seminars involve presentation and discussion of recently published research articles. [
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University of Toronto, Mississauga - Biology Research Project

Students in this course will conduct a research project under the supervision of a faculty member in the Department of Biology. The course is open to third and fourth year students. Students learn how to design, carry out, and evaluate the results of a research project. Students are required to write and present a research proposal, write a term paper, and present a seminar on the results of their research project. All students interested in a research project must approach potential faculty supervisors several months in advance of the beginning of term. Students must obtain permission from the faculty member whom they would like to serve as their project supervisor. Students must meet with the course coordinator three to six times per year.
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University of Toronto, Mississauga - The Study of Matter and Its Transformations

Matter and its transformations are studied at both the microscopic and the macroscopic levels. Topics include atomic and molecular structure, intermolecular forces of attraction and the phases of matter, organic chemical reactions and mechanisms, principles of systems at equilibrium, thermodynamics, electrochemistry and kinetics. [
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University of Toronto, Mississauga - Fundamentals of Analytical Chemistry

A rigorous introduction to the theory and practice of analytical chemistry. Development and applications of basic statistical concepts in treatment and interpretation of analytical data; direct and indirect precipitations; volumetric methods; acid-base, complexometric, redox and precipitation titrations; introduction to instrumental methods; potentiometry and absorption spectroscopy. Applications in biomedical, forensic and environmental areas will be considered. [
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University of Toronto, Mississauga - Introductory Physical Chemistry

Equilibrium thermodynamics and its application to ideal and non-ideal systems: internal energy, enthalpy, entropy, free energy, chemical potential, colligative properties, phase rule and phase diagrams. Kinetics: rate laws, activated complex theory, mechanisms, measurement of very fast reaction rates. [
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University of Toronto, Mississauga - Inorganic Chemistry I

Atomic structure; periodic properties of the elements; bonding theories-ionic, covalent (valence bond and molecular orbital) and metallic; structure and bonding in coordination compounds of main group elements and transition metals; descriptive chemistry of the metals. Reaction mechanisms. [
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University of Toronto, Mississauga - Introductory Organic Chemistry I

Fundamentals of organic chemistry emphasizing reactions of alkanes and alkenes. The first half of a two-course sequence (with
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University of Toronto, Mississauga - Introductory Organic Chemistry II

The chemistry of benzene, alcohols, aldehydes, ketones, carboxylic acid, esters, acid chlorides, amides and amines will be covered. As well, electrophilic aromatic substitution, protection and deprotection of alcohols, nucleophilic acyl substitution, nucleophilic addition, carbonyl alpha-substitution reaction, keto-enol tautomerism, carbonyl ccondensation and proton NMR will be introduced. The emphasis will be on organic mechanisms and application of organic reactions to multistep synthesis. Continues from
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University of Toronto, Mississauga - Research Opportunity Program

This courses provides a richly rewarding opportunity for students in their second year to work in the research project of a professor in return for 299Y course credit. Students enrolled have an opportunity to become involved in original research, learn research methods and share in the excitement and discovery of acquiring new knowledge. Participating faculty members post their project descriptions for the following summer and fall/winter sessions in early February and students are invited to apply in early March. See
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University of Toronto, Mississauga - Instrumental Analytical Chemistry

Introduction to the basic theory and practice underlying important techniques in analytical chemistry, chosen from three major areas of instrumental analysis: spectroscopy, electrochemistry and separation science. Specific topics will include fluorescence spectroscopy, atomic spectroscopy, x-ray fluorescence, voltammetry, high resolution gas and liquid chromatography, mass spectrometry, and a brief introduction to computer applications, including Fourier transform methods. A problem-based approach will be used to explore these methods in a wide variety of practical applications. [
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University of Toronto, Mississauga - Inorganic Chemistry II: Advanced Inorganic Chemistry

Chemistry of metallic elements. Organometallics. Main group and transition elements. Rings, cages and clusters. Lanthanides and Actinides. Applications of IR, UV-VIS and multinuclear NMR spectroscopy. Symmetry. Inorganic synthesis. Non-aqueous solvents. Structure and bonding. Catalysis and industrial processes. [
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University of Toronto, Mississauga - Bioinorganic Chemistry

Principles of inorganic chemical reactions and their application to biochemical systems: kinetics, mechanisms and thermodynamics of ligand exchange, acid-base and redox reactions involving metalloproteins and their model compounds; mechanisms of catalysis by metalloenzymes and their model compounds; therapeutic uses of coordination complexes. [
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University of Toronto, Mississauga - Organic Chemistry: Mechanism and Structure

Stereochemistry and conformational analysis; mechanisms of important types of organic reaction; pericyclic reactions; reactive intermediates. [
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University of Toronto, Mississauga - Organic Synthesis

Methods used for forming carbon-carbon bonds will be reviewed, including reactions of the various types of nucleophilic carbon and the use of organometallic reagents. Other topics include functional group interconversions, oxidation and reduction and the role of elements such as boron, silicon and tin in organic synthesis. [
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University of Toronto, Mississauga - Organic Chemistry of Biological Compounds

The chemistry of selected classes of naturally occurring molecules such as those below, with emphasis on structure, stereochemistry, properties and synthesis. Amino acids, peptides, proteins, carbohydrates, lipids, nucleosides, nucleotides, and nucleic acids. [
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University of Toronto, Mississauga - Structural Biochemistry

An introduction to the molecular anatomy and properties of the major cellular biomolecules: proteins, nucleic acids, carbohydrates and lipids. The course also covers the structural organization of membranes and nucleoproteins. Enzyme mechanisms and membrane transport phenomena will be examined in the context of structure/function relationships.
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University of Toronto, Mississauga - Metabolism and Bioenergetics

Basic principles of biological energetics. Metabolic pathways for carbohydrate and lipid synthesis and degradation. Survey of amino acid and nucleotide metabolism. Integration and cellular regulation of metabolism. Intracellular signal transduction mechanisms. [
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University of Toronto, Mississauga - Techniques in Biological Chemistry

A laboratory course to complement
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University of Toronto, Mississauga - Instrumental Laboratory

This laboratory course represents an integration of the study of fundamental physical chemistry with wide-ranging applications to instrumental methods of analysis, such as separation science, electrochemistry, spectroscopy and computer methods. The course will provide a solid hands-on grounding in many of the major topics covered in analytical and physical chemistry, and the optimization of instrumental analytical measurements by the application of physical principles. Students select from a variety of instruments to customize their program, and develop their own analytical methods to address analytical problems of interest to the student. [
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University of Toronto, Mississauga - Chemical Synthesis Laboratory

This laboratory course comprises the synthesis of inorganic, organometallic, and organic compounds, supplemented by physical measurements (e.g., ir, uv, ¹H NMR spectra, kinetics, etc.) of the products where appropriate. Approximately eight weeks each will be spent on two groups of core experiments, one in organic and one in inorganic synthesis. The remaining eight to ten weeks will be occupied by a choice of inorganic, organometallic, and/or organic experiments. [
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University of Toronto, Mississauga - Research Opportunity

This course provides third-year undergraduate students (after completion of at least 8 to 10 credits) who have developed some knowledge of Chemistry and its research methods, an opportunity to work in the research project of a professor in return for course credit. Students enrolled have the opportunity to become involved in original research, enhance their research skills and share in the excitement of acquiring new knowledge and in the discovery process of science. This course does not count as one of the requirements in the Chemistry Minor, Chemistry Major, Chemistry Specialist or Biological Chemistry Specialist programs. Participating faculty members post their project descriptions for the following summer and fall/winter sessions in early February and students are invited to apply in early March. See
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University of Toronto, Mississauga - Advanced Topics in Analytical Chemistry

Review of recent and fundamental developments of instrumentation that are revolutionizing the field of analytical chemistry as applied to biological chemistry and biotechnology. Topics will include specialized mass spectrometers, secondary ion mass spectrometry, and the GC/MS and LC/MS interfaces; a survey of surface-oriented techniques including electron spectroscopy, attenuated total reflection methods and photoacoustic spectroscopy; Fourier transform theory and methods; microcomputer communication, instrument interfacing and computational methods of chemometrics. [
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